Chiral 3D Covalent Organic Frameworks for High Performance Liquid Chromatographic Enantioseparation

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Date: Jan. 24, 2018
From: Journal of the American Chemical Society(Vol. 140, Issue 3)
Publisher: American Chemical Society
Document Type: Report
Length: 88 words

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Abstract :

The article reports bottom-up synthesis of the first example of 3D chiral covalent organic frameworks (COFs) by imine condensation of an enantiopure 2-fold symmetric TADDOL-derived tetraaldehyde with a tetrahedral tetra(4-anilyl)methane. After postsynthetic oxidation of imine linkages, the framework is transformed into an amide-linked COF with retention of crystallinity and permanent porosity as well as enhanced chemical stability. Both COFs can be used as chiral stationary phases for high performance liquid chromatography to enantioseparate racemic alcohols, and the oxidized COF shows superior separation performance compared to the pristine framework.

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Gale Document Number: GALE|A533972534