The effects of betonicine, floridoside, and isethionic acid from the red alga Ahnfeltiopsis flabelliformis on quorum-sensing activity

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Publisher: Springer
Document Type: Report
Length: 230 words

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Byline: Hai Bo Liu (1), Kyong Pyo Koh (1), Jung Sun Kim (2), Youngwan Seo (3), Sunghoon Park (1) Keywords: quorum-sensing inhibitor; AHL inhibitor; Ahnfeltiopsis flabelliformis; Agrobacterium tumefaciens; betonicine; floridoside; isethionic acid Abstract: A mixture of three compounds (betonicine, floridoside, and isethionic acid) purified from the red alga Ahnfeltiopsis flabelliformis, was reported to have an inhibition activity on bacterial quorum sensing mechanism mediated by Noctanoyl-dl-homoserine lactone (OHL) and the TraR transcriptional activator protein. We subsequently conducted a more detailed investigation of the three compounds using chemically synthesized (betonicine and floridoside) or commercially available (isethionic acid) compounds, individually or in various combinations. When tested alone, none of the three compounds inhibited OHL, but a mixture of floridoside and isethionic acid exhibited a dose-dependent inhibitory effect on the function of OHL. In contrast, betonicine or its isomer exhibited a dose-dependent stimulatory effect, similar to OHL, at concentrations between 10.sup.-3 and 10.sup.-6 M. These three compounds will be useful for elucidating the interaction between OHL and TraR, and for developing novel bacterial quorum-sensing inhibitors. Author Affiliation: (1) Department of Chemical and Biochemical Engineering and Institute for Environmental Technology and Industry, Pusan National University, Busan, 609-735, Korea (2) Division of Health Science, Dongseo University, Busan, 617-716, Korea (3) Division of Marine Environment and Bioscience, Korea Maritime University, Busan, 606-791, Korea Article History: Registration Date: 18/09/2008 Received Date: 27/05/2008 Accepted Date: 30/06/2008 Online Date: 20/09/2008

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Gale Document Number: GALE|A228117186