Daphnetin Ameliorates Corticosterone-lnduced Depressive-Like Behavior and Oxidative Stress in Mice Via Nuclear Factor Erythroid 2-Related Factor/Heme Oxygenase-1 Pathway.

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Authors: Chao Liu, Chao Liang and Jie Huang
Date: Nov. 2021
Publisher: New Century Health Publishers, LLC
Document Type: Article
Length: 4,161 words
Lexile Measure: 1350L

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Abstract :

We have investigated the effect of daphnetin on depressive-like behavior and oxidative stress caused by corticosterone in mice. To this end, we have analyzed the effect of corticosterone alone and combination of corticosterone and daphnetin on three Pehavioral indices of depressive-like Pehavior - sucrose consumption rate, forced swimming test, and tail suspension test as well as biochemical markers of oxidative stress - malondialdehyde, nitrite, protein carbonyl, nonprotein sulf-hydryl and glutathione contents as well as hippocampal cell apoptosis. The results support the conclusion that daphnetin diminished corticosterone induced depressive like behavior and oxidative stress by activating Nrf2/HO-1 pathway. Keywords: Corticosterone, Daphnetin, Depressive-like behavior, Oxidative stress Abbreviations Used: BCL2-associated X protein, Bax; B-cell lymphoma-2, Bcl-2; Corticosterone, CORT; Daphnetin, DAP; Dimethyl sulfoxide, DMSO; Electrochemiluminescence, ECL; Enzyme-linked immunosorbent assay, ELISA; Forced swimming test, FST; Glutathione, GSH; Heme oxygenase-1, HO-1; Horseradish peroxidase, HRP; Ischemia-reperfusion, l/R; Malondialdehyde, MDA; Nonprotein sulfhydryl, NPSH; Nuclear factor erythroid 2-related factor, Nrf2; Protein carbonyl, PC; Thiobarbituric acid reactive substances, TBARS; Tail suspension test, TST; Terminal dUTP nick-end labeling, TUNEL

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Gale Document Number: GALE|A670225508