The H-Wave(r) device is an effective and safe non-pharmacological analgesic for chronic pain: a meta-analysis

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From: Advances in Therapy(Vol. 25, Issue 7)
Publisher: Springer
Document Type: Report
Length: 520 words

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Byline: Kenneth Blum (1,12), Amanda LC Chen (2), Thomas JH Chen (2), Thomas J. Prihoda (3), John Schoolfield (4), Nicholas DiNubile (5,6), Roger L. Waite (7), Vanessa Arcuri (8,9), Mallory Kerner (8,9), Eric R. Braverman (8,9), Patrick Rhoades (10), Howard Tung (11) Keywords: analgesia; functionality; H-Wave device and programme; meta-analysis; pain medication; pain relief Abstract: Introduction This meta-analysis was conducted to systematically review the efficacy and safety of the H-Wave(r) (Electronic Waveform Lab, Inc, Huntington Beach, CA, USA) device and programme as a non-pharmacological analgesic treatment in chronic soft tissue inflammation and neuropathic pain. Methods Five studies related to pain relief, reduction in pain medication and increased functionality obtained with the H-Wave device were included in the analysis. Data were analysed using the random effects model, including adjustment to evaluate variability, size of study and bias in effect size. A total of 6535 participants were included in the meta-analysis there were 8065 participants outcomes measured due to multiple measurements per participant. Results The H-Wave device decreased pain ratings across various chronic soft tissue inflammation and neuropathic pain conditions. The mean weighted effect size was 0.59, and the estimated effect size variance was 0.00003 (95% confidence intervals [CI]: 0.580, 0.600). The H-Wave device also decreased the intake of pain medication in patients with various chronic soft tissue inflammation and neuropathic pain conditions. The mean weighted effect size was 0.56, and the estimated effect size variance was 0.000013 (95% CI: 0.553, 0.567). Patient functionality was also improved with use of the H-Wave device. The mean weighted effect size was 0.70, and the estimated effect size variance was 0.00002 (95% CI: 0.691, 0.709). A chi-square test for homogeneous effect sizes found highly significant (P Conclusion The findings indicate a moderate to strong effect of the H-Wave device in providing pain relief, reducing the requirement for pain medication and increasing functionality. The most robust effect was observed for improved functionality, suggesting that the H-Wave device may facilitate a quicker return to work and other related daily activities. Author Affiliation: (1) Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, North Carolina, USA (2) Chang Jung Christian University, Taiwan, Republic of China (3) Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA (4) Department of Academic Informatics Services, University of Texas Health, Science Center, San Antonio, Texas, USA (5) Havertown, Pennsylvania, USA (6) Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA (7) LifeGen, Inc, La Jolla, California, USA (8) PATH Medical Center, New York, USA (9) Department of Neurological Surgery, Weill Cornell Medical College, New York, USA (10) Central Valley Pain Clinic, Modesto, California, USA (11) Department of Neurosurgery, University of California San Diego, School of Medicine, San Diego, California, USA (12) Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC, 27157, USA Article History: Registration Date: 15/07/2008 Online Date: 18/07/2008

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Gale Document Number: GALE|A228118020