Total synthesis of uvaricin

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Date: Aug. 21, 1998
From: Journal of Organic Chemistry(Vol. 63, Issue 17)
Publisher: American Chemical Society
Document Type: Article
Length: 57 words

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Abstract :

Research was conducted to develop the first total synthesis of naturally occurring (+)-uvaricin. The methodology employed were three consecutive Sharpless asymmetric dihydroxylation reactions to incorporate the necessary stereochemical features in a regio- and enantioselectively controlled manner. A Williamson type etherification reaction was used on a functionalized bis-mesylate intermediate for the construction of the appropriate bis-THF ring system.

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Gale Document Number: GALE|A21134950