Impact of 0.1% sodium hyaluronate and 0.2% sodium hyaluronate artificial tears on postoperative discomfort following cataract extraction surgery: a comparative study

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From: Eye and Vision(Vol. 6, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 3,356 words
Lexile Measure: 1450L

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Abstract :

Background Recent artificial tear preparations have provided 0.2% concentration of sodium hyaluronate. However, no published data exist on their potential superiority against 0.1% in alleviating dry-eye-disease symptoms in cataract extraction surgery. Methods A total of 180 patients that underwent cataract extraction surgery were randomly divided into 2 groups according to their postoperative regime: Study group (SG) received fixed combination of tobramycin and dexamethasone (FCTD) quid for 3 weeks, and additionally 0.2% sodium hyaluronate provided in the COMOD[R] device quid for 6 weeks. Control group (CG) received fixed combination of tobramycin and dexamethasone (FCTD) quid for 3 weeks, and additionally 0.1% sodium hyaluronate provided in the COMOD[R] device quid for 6 weeks. The following indexes were evaluated at 3 postoperative checkpoints: 1) Surface discomfort index (SDI) which was derived by four direct 10-scale Likert-type questions that were addressed to the patient and pertained to: a) foreign body sensation (FBS), b) blinking discomfort (BD), c) stinging sensation (SS), d) tearing sensation (TS), 2) Tear break-up time (TBUT), 3) Schirmer's test, 4) Central corneal thickness (CCT), and 4) Central Corneal Sensitivity (CCS). Results Both groups showed reduced CCS values at all postoperative examination points; however, SG participants had significantly better CCS (all p Conclusion The increased 0.2% sodium hyaluronate concentration in the artificial tears provided in the COMOD[R] device seems to address dry-eye-disease symptoms better in patients who underwent phacoemulsification surgery than the 0.1% concentration. Trial registration ClinicalTrials.govIdentifier:NCT03705949 Oct 15, 2018, retrospectively registered. Keywords: Cataract, Postoperative regime, Artificial tears, Surface discomfort index, Hylocomod, Hylogel, Sodium hyaluronate

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Gale Document Number: GALE|A573911955