Prognostic value of fibrosis ratio in metastatic lymph nodes of node-positive advanced gastric cancer.

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From: Medicine(Vol. 97, Issue 1)
Publisher: Lippincott Williams & Wilkins, WK Health
Document Type: Article
Length: 387 words

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Byline: Soon Auck Hong, Department of Pathology Department of General Surgery, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan Department of Pathology, Armed Force Capital Hospital, Seongnam Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.; Myoung Won Son; Junhun Cho; Chung Hun Lee; Si-Hyeong Jang; Hyun Ju Lee; Ji-Hye Lee; Hyun Deuk Cho; Mee-Hye Oh; Kyu-Taek Lee; Moon Soo Lee Abstract Lymph node metastasis plays a crucial role in predicting prognosis in advanced gastric cancer (AGC). In the present study, we formulated a fibrosis ratio (FR), defined as the number of metastatic lymph nodes with fibrosis divided by the total number of lymph nodes, and sought to determine whether it can be used to predict the prognosis of patients with AGC and improve on existing node staging. We retrospectively analyzed 161 patients who underwent curative resection for node-positive AGC between 2001 and 2010, evaluating the association between FR, lymph node ratio (LNR), and micrometastasis, and the relationship between FR and clinicopathologic findings, overall survival (OS) and disease-free survival (DFS). A high FR was significantly related to T stage (PÇè

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Gale Document Number: GALE|A671667208