A single IGF1 allele is a major determinant of small size in dogs

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From: Science(Vol. 316, Issue 5821)
Publisher: American Association for the Advancement of Science
Document Type: Article
Length: 126 words
Lexile Measure: 1590L

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Abstract :

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (OTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single 16F1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

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Gale Document Number: GALE|A162576089