Effects of rs591323 on serotonin transporter availability in healthy male subjects

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From: Annals of Nuclear Medicine(Vol. 32, Issue 7)
Publisher: Springer
Document Type: Report
Length: 413 words

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To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12149-018-1262-z Byline: Kyoungjune Pak (1), Hyun-Yeol Nam (2), Seunghyeon Shin (1), Keunyoung Kim (1), Myung Jun Lee (3), Eun-Joo Kim (3), Jae Meen Lee (4), Seong-Jang Kim (5), In Joo Kim (1) Keywords: SPECT; Serotonin transporter; Single nucleotide polymorphism Abstract: Objectives We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls. Methods The study population consisted of healthy controls with screening 123.sup.I-FP-CIT single-photon emission computed tomography. Specific binding of 123.sup.I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons. Results One hundred sixty healthy controls (male 106, female 54, 61.0[+ or -]11.5 years) were included in this study. Sex difference did not exist in DAT availabilities of caudate nucleus (p=0.5344), putamen (p=0.5006), and striatum (p=0.5056). However, male subjects had higher SERT availabilities of both midbrain (p=0.0436), and pons (p=0.0061). Therefore, we analyzed the effect of SNP on DAT availabilities of subjects in all, and that on SERT availabilities of males and females separately. None of 19 SNPs included in this study showed the effect on DAT availabilities. However, rs591323 in Fibroblast Growth Factor 20 on chromosome 8 had a significant impact on SERT availability of both midbrain (p=0.0056) and pons (p=0.0007). Conclusion SNP rs591323 of risk loci for Parkinson's disease is associated with SERT availability of healthy male subjects. Author Affiliation: (1) 0000 0000 8611 7824, grid.412588.2, Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea (2) 0000 0001 2181 989X, grid.264381.a, Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea (3) 0000 0000 8611 7824, grid.412588.2, Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea (4) 0000 0000 8611 7824, grid.412588.2, Department of Neurosurgery and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea (5) 0000 0004 0442 9883, grid.412591.a, Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea Article History: Registration Date: 14/05/2018 Received Date: 14/03/2018 Accepted Date: 13/05/2018 Online Date: 17/05/2018 Article note: Kyoungjune Pak, Hyun-Yeol Nam, Seong-Jang Kim and In Joo Kim contributed equally as corresponding authors in this work.

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Gale Document Number: GALE|A547384087