Managing Clostridium difficile in Inflammatory Bowel Disease (IBD)

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Date: July 2014
From: Current Gastroenterology Reports(Vol. 16, Issue 7)
Publisher: Springer
Document Type: Report
Length: 222 words

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Abstract :

Byline: Jana G. Hashash (1), David G. Binion (1) Keywords: C. difficile infection; Inflammatory bowel disease; IBD; Metronidazole; Vancomycin; Fecal microbiome transplant Abstract: Clostridium difficile (C. difficile) infection has emerged as a significant clinical challenge for patients suffering from inflammatory bowel disease (IBD). C. difficile can both precipitate and worsen flares of IBD, contributing to emergent colectomies and mortality. Advances in the management of C. difficile infection in IBD include recommendations for testing for this infection in the setting of clinical flare and hospitalization, improved diagnostic testing, identification of high rates of carriage and infection in pediatric IBD, and new data associating patterns of IBD genetic risk alleles with the development of this infection. Therapeutically, oral vancomycin has emerged as a superior treatment for IBD patients with moderate to severe disease compared with metronidazole. Although highly effective in the general population, fecal microbiome transplantation for recurrent C. difficile infection in IBD patients has been associated with colitis flare in the majority of patients who have received this treatment. Author Affiliation: (1) Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Mezzanine Level C Wing PUH, Pittsburgh, PA, 15213, USA Article History: Registration Date: 10/04/2014 Online Date: 18/05/2014 Article note: This article is part of the Topical Collection on Inflammatory Bowel Disease

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Gale Document Number: GALE|A376920553