Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy).sub.2(2-MIM)(NO)](PF.sub.6).sub.3] in the respiratory mechanics of Swiss mice.

Citation metadata

From: PLoS ONE(Vol. 16, Issue 3)
Publisher: Public Library of Science
Document Type: Report
Length: 6,773 words
Lexile Measure: 1520L

Document controls

Main content

Abstract :

We aimed at evaluating the anti-asthmatic effect of cis-[Ru(bpy).sub.2 (2-MIM)(NO)](PF.sub.6).sub.3 (FOR811A), a nitrosyl-ruthenium compound, in a murine model of allergic asthma. The anti-asthmatic effects were analyzed by measuring the mechanical lung and morphometrical parameters in female Swiss mice allocated in the following groups: untreated control (Ctl+Sal) and control treated with FOR811A (Ctl+FOR), along asthmatic groups untreated (Ast+Sal) and treated with FOR811A (Ast+FOR). The drug-protein interaction was evaluated by in-silico assay using molecular docking. The results showed that the use of FOR811A in experimental asthma (Ast+FOR) decreased the pressure-volume curve, hysteresis, tissue elastance, tissue resistance, and airway resistance, similar to the control groups (Ctl+Sal; Ctl+FOR). However, it differed from the untreated asthmatic group (Ast+Sal, p

Source Citation

Source Citation   

Gale Document Number: GALE|A654753564