Improved outcome in asymptomatic recurrence following curative surgery for gastric cancer

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From: Medical Oncology(Vol. 28, Issue 4)
Publisher: Springer
Document Type: Report
Length: 309 words

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Byline: Cynthia Villarreal-Garza (1), Miriam Rojas-Flores (1), Andrea Castro-Sanchez (1), Antonio R. Villa (2), Luis Garcia-Aceituno (1), Eucario Leon-Rodriguez (1) Keywords: Gastric cancer; Asymptomatic recurrence; Re-resection; Follow-up Abstract: The purpose of this study was to compare the outcome and resectability of patients with gastric cancer recurrence after curative surgery detected by follow-up endoscopy, according to the presence or absence of symptoms. All patients with gastric carcinoma, who underwent a curative gastrectomy, were retrospectively identified. We analyzed outcome and survival in patients compliant with routine follow-up who presented symptomatic and asymptomatic recurrence. Of the 119 resected patients, 63.0% had a recurrence, with an overall survival of 20.0 months. Fourteen patients were asymptomatic when recurrence was detected, whereas 61 patients were symptomatic. Median time to recurrence was 16.0 m for both groups. A local curative re-resection was possible in 2/14 (asymptomatic) and 1/61 (symptomatic). Asymptomatic patients had a longer median postrecurrence survival time of 9.0 months, compared with 2.0 months in the symptomatic patients (p=0.034). The median overall survival was greater in the asymptomatic vs symptomatic group (25.0 vs 20.0 months), although this did not reach statistical significance. The results from this study advocate that the presence or absence of symptoms is a good surrogate marker to assess biologic aggressiveness. The value of routine follow-up endoscopy to permit a higher rate of re-resection in asymptomatic patients remains to be established. Author Affiliation: (1) Department of Medical Oncology and Hematology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Vasco de Quiroga 15, Seccion XVI. Del. Tlalpan, C.P. 14000, Mexico City, DF, Mexico (2) Department of Clinical Epidemiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Mexico City, DF, Mexico Article History: Registration Date: 17/05/2010 Received Date: 15/03/2010 Accepted Date: 17/05/2010 Online Date: 02/06/2010 Article note: Presented at 2008 ASCO Annual Meeting, May 30-June 3, 2008 in Chicago, Ill.

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Gale Document Number: GALE|A272742271