Genetic Landscape of Primary Versus Metastatic Colorectal Cancer: to What Extent Are They Concordant?

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From: Current Colorectal Cancer Reports(Vol. 11, Issue 5)
Publisher: Springer
Document Type: Report
Length: 227 words

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Byline: Claudia Cardone (1), Giulia Martini (1), Teresa Troiani (1), Stefania Napolitano (1), Francesco Selvaggi (2), Fortunato Ciardiello (1), Erika Martinelli (1) Keywords: Colorectal cancer; Genetic landscape; Tumor cell fraction; DNA copy number alterations; RAS; BRAF; P53; PTEN; PI3KCA; MACC1; FBXW7 Abstract: Recent developments in genomic technologies have led an unprecedented view of the profound molecular complexity of colorectal cancer (CRC) and its evolution. The genomic landscape of CRC is characterized by a high heterogeneous landscape both at an intratumoral and at an inter-metastatic and intrametastatic level. In the era of personalized cancer medicine, the challenge is the definition of predictive biomarkers in respect of a such complex scenario. Despite the robust differences occurring between primary tumor and metastatic sites, the biomarkers currently validated in clinical practice have high concordance. The purpose of this review is to explore differences existing in genetic landscape of primary tumor and metastatic sites in CRC, in order to assess concordance and discordance rates of biologic events between different tumor lesions in CRC. Author Affiliation: (1) Second University of Naples, Via Pansini 5, 80131, Naples, Italy (2) Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy Article History: Registration Date: 29/05/2015 Online Date: 12/06/2015 Article note: This article is part of the Topical Collection on Therapeutic Approaches to Metastatic Colorectal Cancers Claudia Cardone and Giulia Martini contributed equally to this work.

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Gale Document Number: GALE|A426787208