Cytotoxic phenolic compounds from Chionanthus retusus

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From: Archives of Pharmacal Research(Vol. 32, Issue 12)
Publisher: Springer
Document Type: Report
Length: 206 words

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Byline: Jong Hwan Kwak (1), Min Woo Kang (1), Jong Hwa Roh (1), Sang Un Choi (2), Ok Pyo Zee (1) Keywords: Chionanthus retusus; Oleaceae; Phenolic compounds; Cytotoxicity Abstract: Cytotoxicity-guided fractionation and purification of MeOH extract from Chionanthus retusus Lindl. et Paxton resulted in the isolation of compounds. Fourteen phenolic compounds were isolated from the EtOAc soluble fraction, and their structures were determined by spectroscopic analysis. Isolated compounds were identified as phillygenin (1), scopoletin (2), pinoresinol (3), kaempferol (4), aromadendrin (5), 2-(4-hydroxyphenyl)ethanol (6), 3,3 ,5,5 ,7-pentahydroxyflavanone (7), luteolin (8), quercetin (9), apigenin (10), chrysoeriol (11), phillyrin (12), oleuropein (13), (7R,8R)-guaiacylglycerol (14). All compounds except for 12 and 13 were isolated for the first time from this plant and genus Chionanthus. Anti-proliferative effect of isolated compounds were evaluated by the sulforhodamin B assay against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 4 and 8--10 were significantly active with ED50 values of 1.84--6.35 ug/mL. Also, compounds 1, 3, 5 and 7 revealed cytotoxic effects at concentrations below 30 ug/mL. Author Affiliation: (1) College of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea (2) Korea Research Institute of Chemical Technology, Taejeon, 305-600, Korea Article History: Registration Date: 16/02/2009 Received Date: 07/08/2009 Accepted Date: 13/08/2009 Online Date: 17/02/2010

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Gale Document Number: GALE|A228117603