Next Generation Vaccines for Infectious Diseases

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Publisher: Hindawi Limited
Document Type: Article
Length: 721 words
Lexile Measure: 1500L

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Vaccines represent the most effective prophylactic strategy in our arsenal for controlling the spread of infectious diseases and have increased human life expectancy. As an example, the eradication of smallpox and the massive reduction of other infectious diseases such as polio, measles, and diphtheria represent major vaccination victories of the last century. Despite the important successes achieved through vaccination, ongoing efforts continue towards development of new and more protective vaccines. Namely, a number of challenges still remain in the context of vaccination. Specifically, many commercially available vaccines fail to elicit long-lasting immune responses and insufficiently trigger cell-mediated and mucosal immunity. Moreover, many vaccines remain dependent on a cold chain for maintenance of antigenicity and potency. Finally, vaccine compliance remains an issue in our society.

Most often, vaccines are composed of attenuated or inactivated pathogens and are capable of eliciting a protective immune response while avoiding the complications associated with an infection. In recent years, thanks to advances in biotechnology and improvements in the production of recombinant proteins, other vaccine strategies have been developed and approved for human use. Many other...

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Gale Document Number: GALE|A613397071