Early-onset neonatal sepsis by Group b Streptococcus in a Brazilian public hospital

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Publisher: Contexto
Document Type: Letter to the editor
Length: 809 words
Lexile Measure: 1480L

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Dear Editor,

Despite the known efficacy of the intrapartum antibiotic prophylaxis (IAP), (1) no Group B Streptococcus (GBS) prophylaxis program are in place in Brazil, (2) and rates of early-onset sepsis (EOS) may be underestimated. We conducted a retrospective analysis on the incidence EOS, IAP use and outcomes of infants born in a Brazilian University Hospital (Hospital de Clinicas de Uberlandia, HC-U). An early-onset GBS sepsis episode was defined based on positive blood cultures in the first 72 h of postnatal life. Blood cultures for all newborn infants with suspected sepsis were performed by an automated system (Vitek 2 system BioMerieux, France). Maternal/infant demographic and clinical data were obtained from the medical records. The study was approved by the University Hospital Ethics Committee (protocol 394/09).

From January 2008 to December 2011, there were 8818 live births. Among them, we identified eight infants with confirmed early-onset GBS sepsis. The overall incidence rate was 0.90 cases per 1000 live births. Infants' characteristics and clinical outcomes are shown in Table 1. All neonates were born vaginally. The average hospital length of stay was eight days (range: 1-36 days). The case-fatality rate was 50% (4/8), occurring in the first four days of life. Out of four...

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Gale Document Number: GALE|A509972163