Primary fallopian tube carcinoma: A case of rare malignancy

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Date: September-December 2018
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Case study; Report
Length: 1,714 words
Lexile Measure: 1340L

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Byline: Preeti. Chakrabarti, Sudipta. Bera, Satyadev. Rana

Primary fallopian tube carcinoma is an extremely uncommon tumor of female genital tract origin with the incidence of 0.1%-1.8% of all genital malignancies. Due to its nonspecific symptomatology and rarity of this neoplasm, correct preoperative diagnosis is made only in 4% of the cases and is usually first recognized by pathologist. Our case was a 39-year-old patient who presented with intermittent vaginal bleeding, lower abdominal pain, and pelvic mass. On physical examination, lower abdominal tenderness was found. Ultrasound examination revealed bilateral hydrosalpinx. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination confirmed features of papillary serous adenocarcinoma of the left fallopian tube. The patient was referred to oncologist for chemotherapy. Six months following initial surgery, the patient is in good condition. This case is being reported due to the scarcity of data published from the Indian population and rarity of this neoplasm.


Primary fallopian tube carcinoma (PFTC) is a rare gynecological tumor accounting for an approximately 0.14%-1.8% of female genital tract malignancies.[1],[2] It was first described by Renaud in 1847. In 1888, Orthmann presented the first case report.[3] PFTC is rarely diagnosed preoperatively due to its nonspecific symptomatology.[4] The etiology of this cancer is not known; its association with infertility, tuberculous salpingitis, chronic tubal inflammation, infertility, and tubal endometriosis has been reported.[5] An ovarian and fallopian tube malignancy shared similar BRCA germline and TP53 mutations.[6] Herein, we report a case of PFTC in a 39-year-old female with a review of literature due to its rarity of presentation.

Case Report

A 39-year-old patient was presented with abnormal vaginal bleeding for the past 4 months and dysmenorrhea for 1 year. She also complained of lower abdominal pain which was dull in nature and intermittently radiated to back. There was no significant family history. She was known hypertensive and diabetic and was on medication for the same for the past 3 years.

On physical examination, she had lower abdominal tenderness. Per speculum examination revealed mild vaginal bleeding with healthy cervix and vagina. Transabdominal sonography showed bilateral hydrosalpinx and myoma measuring 36 mm x 34 mm. A diagnostic curettage was previously performed which revealed simple hyperplasia of the endometrium. The serum levels of cancer antigen (CA)-125 (11.8U/ML), alpha-fetoprotein (2.52 ng/ml), and CA-19.9 (21.7U/ML) were within normal limits. The patient after an informed consent underwent total abdominal hysterectomy withbilateral salpingo-oopherectomy. On gross examination of lymph node stations intraoperatively were unremarkable. Specimens were received in histopathology section.

Gross examination revealed uterus with cervix with bilateral adnexa, uterus with cervix measured 10 cm x 8...

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Gale Document Number: GALE|A567402900