Obesity, insulin resistance and their interaction on liver enzymes.

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Date: Apr. 21, 2021
From: PLoS ONE(Vol. 16, Issue 4)
Publisher: Public Library of Science
Document Type: Report
Length: 3,849 words
Lexile Measure: 1500L

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Abstract :

Introduction To investigate weight status, insulin resistance assessed by HOMA-IR, and their interaction on liver function in non-diabetic Chinese adults. Methods and results A total of 7066 subjects were included, and divided into normal weight (n = 3447), overweight (n = 2801), and obese (n = 818) groups. Data including weight, height, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, y-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were acquired. In multi-linear regression analysis for liver enzymes as dependent variables, insulin resistance emerged as a determinant of ALT ([beta] = 0.165, P Conclusion Insulin resistance had significant associations with greater risk of elevated ALT, AST and GGT level in non-diabetic Chinese adults, especially among those who were overweight/ obese.

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Gale Document Number: GALE|A659212255