Airborne aerosol olfactory deposition contributes to anosmia in COVID-19

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From: PLoS ONE(Vol. 16, Issue 2)
Publisher: Public Library of Science
Document Type: Report
Length: 2,207 words
Lexile Measure: 1570L

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Abstract :

Introduction Olfactory dysfunction (OD) affects a majority of COVID-19 patients, is atypical in duration and recovery, and is associated with focal opacification and inflammation of the olfactory epithelium. Given recent increased emphasis on airborne transmission of SARS-CoV-2, the purpose of the present study was to experimentally characterize aerosol dispersion within olfactory epithelium (OE) and respiratory epithelium (RE) in human subjects, to determine if small (sub 5[mu]m) airborne aerosols selectively deposit in the OE. Methods Healthy adult volunteers inhaled fluorescein-labeled nebulized 0.5-5[mu]m airborne aerosol or atomized larger aerosolized droplets (30-100[mu]m). Particulate deposition in the OE and RE was assessed by blue-light filter modified rigid endoscopic evaluation with subsequent image randomization, processing and quantification by a blinded reviewer. Results 0.5-5[mu]m airborne aerosol deposition, as assessed by fluorescence gray value, was significantly higher in the OE than the RE bilaterally, with minimal to no deposition observed in the RE (maximum fluorescence: OE 19.5(IQR 22.5), RE 1(IQR 3.2), p Conclusions Our data experimentally confirm that despite bypassing the majority of the upper airway, small-sized (0.5-5[mu]m) airborne aerosols differentially deposit in significant concentrations within the olfactory epithelium. This provides a compelling aerodynamic mechanism to explain atypical OD in COVID-19.

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Gale Document Number: GALE|A650856551