Behavioral animal models of depression

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Date: Aug. 2010
From: Neuroscience Bulletin(Vol. 26, Issue 4)
Publisher: Springer
Document Type: Article
Length: 278 words

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Abstract :

Byline: Hua-Cheng Yan (1), Xiong Cao (1), Manas Das (1), Xin-Hong Zhu (1), Tian-Ming Gao (1) Keywords: depression; animal models; learned helplessness; chronic mild stress; social defeat; forced swimming test; tail suspension test; aeec; a"c(c)ae"!a; e*a3/4aeSSae a(c); aeC/aeSSae,(c)aaoae?; c$?3/4a1/4a$?+-e'Y=aoae?; a1/4oe? Abstract: Depression is a chronic, recurring and potentially life-threatening illness that affects up to 20% of the population across the world. Despite its prevalence and considerable impact on human, little is known about its pathogenesis. One of the major reasons is the restricted availability of validated animal models due to the absence of consensus on the pathology and etiology of depression. Besides, some core symptoms such as depressed mood, feeling of worthlessness, and recurring thoughts of death or suicide, are impossible to be modeled on laboratory animals. Currently, the criteria for identifying animal models of depression rely on either of the 2 principles: actions of known antidepressants and responses to stress. This review mainly focuses on the most widely used animal models of depression, including learned helplessness, chronic mild stress, and social defeat paradigms. Also, the behavioral tests for screening antidepressants, such as forced swimming test and tail suspension test, are also discussed. The advantages and major drawbacks of each model are evaluated. In prospective, new techniques that will be beneficial for developing novel animal models or detecting depression are discussed. aeecae-a,cSSaeC/aeSSca a*aee !a-1aPccccaeoaPaoeSSPScadeg, e?a, e|a1/2a aoc1/4oa1aeaea-e ca"c(c)ae"!aa ae$?a$?, aeeccae ,a?ccP, a3/4a|aeea?aC/a ae a *a1/4aeaaa$?aocdegeaaea?ua$?'c, aae ae3a"a(r)eaa"c(c)a,a3/4a Y=ae"!aea c(r)a, a$?SSe"aa"c(c)ae"!aca oc e|acSSa Y=a,a,$?a,aaaa1a,: a-1aoa*2cY=aeaeee-ca1/2c"aeeae-a-1aoae?caaoa ae!c 1/4e?dega, e|a c c(r)aaea,,c"ca a,a aeeca"c(c)ae"!a, aae!e*a3/4aeSSae a(c)a aeC/aeSSae,(c)aaoae?ac$?3/4a1/4a$?+-e'Y=aoae?, a Y=aa,aoc"aoceaeaeaeeae' aeSSe-c(c)ce!a,o a|aePSaeuae1ae3(a|a1/4oe? !ca1/4c1a,a,eP3e?e!e(r)"e(r)oa aea, a-1a"c(c)ae"!aae!a,oa|aePSaeu ae1ae3caa+-ae1ae?e!a+-aea Author Affiliation: (1) Department of Neurobiology, Southern Medical University, Guangzhou, 510515, China Article History: Registration Date: 02/08/2010 Received Date: 24/03/2010 Accepted Date: 04/06/2010 Online Date: 06/08/2010

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Gale Document Number: GALE|A233715012