Water Exchange across the Blood-Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion-Weighted Pseudo-Continuous Arterial Spin Labeling Study

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From: Journal of Neuroimaging(Vol. 25, Issue 6)
Publisher: Wiley Subscription Services, Inc.
Document Type: Report
Length: 418 words

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Byline: , , Danny J.J. Wang, Bumhee Park, Mary A. Woo, Daniel W. Kang, Keith S. St Lawrence, Ronald M. Harper, Rajesh Kumar Keywords: Magnetic resonance imaging; pseudo-continuous arterial spin labeling; arterial transient time; autonomic control ABSTRACT BACKGROUND AND PURPOSE Obstructive sleep apnea (OSA) subjects show brain injury in sites that control autonomic, cognitive, and mood functions that are deficient in the condition. The processes contributing to injury may include altered blood-brain barrier (BBB) actions. Our aim was to examine BBB function, based on diffusion-weighted pseudo-continuous arterial spin labeling (DW-pCASL) procedures, in OSA compared to controls. METHODS We performed DW-pCASL imaging in nine OSA and nine controls on a 3.0-Tesla MRI scanner. Global mean gray and white matter arterial transient time (ATT, an index of large artery integrity), water exchange rate across the BBB (Kw, BBB function), DW-pCASL ratio, and cerebral blood flow (CBF) values were compared between OSA and control subjects. RESULTS Global mean gray and white matter ATT (OSA vs. controls; gray matter, 1.691 [+ or -] .120 vs. 1.658 [+ or -] .109 second, P = .49; white matter, 1.700 [+ or -] .115 vs. 1.650 [+ or -] .114 second, P = .44), and CBF values (gray matter, 57.4 [+ or -] 15.8 vs. 58.2 [+ or -] 10.7 ml/100 g/min, P = .67; white matter, 24.2 [+ or -] 7.0 vs. 24.6 [+ or -] 6.7 ml/100 g/min, P = .91) did not differ significantly, but global gray and white matter Kw (gray matter, 158.0 [+ or -] 28.9 vs. 220.8 [+ or -] 40.6 min.sub.-1, P = .002; white matter, 177.5 [+ or -] 57.2 vs. 261.1 [+ or -] 51.0 min.sub.-1, P = .006), and DW-pCASL ratio (gray matter, .727 [+ or -] .076 vs. .823 [+ or -] .069, P = .011; white matter, .722 [+ or -] .144 vs. .888 [+ or -] .100, P = .004) values were significantly reduced in OSA over controls. CONCLUSIONS OSA subjects show compromised BBB function, but intact large artery integrity. The BBB alterations may introduce neural damage contributing to abnormal functions in OSA, and suggest a need to repair BBB function with strategies commonly used in other fields. Article Note: Acknowledgments and Disclosure: We thank Ms. Karen Harada and Ms. Kelly Hickey for assistance with data collection. This research was supported by National Instututes of Health R01 HL-113251 and R01 NR-015038. Dr. Wang was also supported by National Instututes of Health R01-NS081077 and R01-EB014922. Jose A. Palomares and Sudhakar Tummala contributed equally.

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Gale Document Number: GALE|A431741174