Nonfilamentous C. albicans mutants are avirulent

Citation metadata

From: Cell(Vol. 90, Issue 5)
Publisher: Elsevier B.V.
Document Type: Article
Length: 61 words

Document controls

Main content

Abstract :

Candida albicans, a fungal pathogen, can change from a yeast to a filamentous form. Two regulatory proteins Ste12p and Phd1p regulate the change in Saccharomyces. Single-mutant strains are partly defective, whereas the double mutant is entirely defective and noninvasive in filamentous growth. In a mouse model, the Candida cph1/chh1 efg1/efg1 double mutant in the yeast form, was found to be avirulent.

Source Citation

Source Citation   

Gale Document Number: GALE|A19974476