Sex difference in the near-24-hour intrinsic period of the human circadian timing system

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Publisher: National Academy of Sciences
Document Type: Author abstract
Length: 287 words

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Abstract :

The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Although the neurobiological mechanism underlying this sex difference in circadian alignment is unknown, multiple studies in nonhuman animals have demonstrated a sex difference in circadian period that could account for such a difference in circadian alignment between women and men. Whether a sex difference in intrinsic circadian period in humans underlies the difference in circadian alignment between men and women is unknown. We analyzed precise estimates of intrinsic circadian period collected from 157 individuals (52 women, 105 men; aged 18-74 y) studied in a month-long inpatient protocol designed to minimize confounding influences on circadian period estimation. Overall, the average intrinsic period of the melatonin and temperature rhythms in this population was very close to 24 h [24.15 [+ or -] 0.2 h (24 h 9 rain [+ or -] 12 min)]. We further found that the intrinsic circadian period was significantly shorter in women [24.09 [+ or -] 0.2 h (24 h 5 min [+ or -] 12 min)] than in men [24.19 [+ or -] 0.2 h (24 h 11 min [+ or -] 12 min); P biological rhythm | gender | phase angle doi/ 10.1073/pnas.1010666108

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Gale Document Number: GALE|A268961019