Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell

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Date: Feb. 17, 2010
From: Journal of Ethnopharmacology(Vol. 127, Issue 3)
Publisher: Elsevier B.V.
Document Type: Article
Length: 114 words

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Abstract :

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jep.2009.12.008 Byline: Yu-Yi Chan, Chun-Sheng Chang, Lan-Hsiang Chien, Ting-Feng Wu Keywords: Antrodia camphorata; A549 cell; Galectin-1; Alcohol extract; Rho GDP dissociation inhibitor [alpha]; Calpain 1/2 small subunit Abstract: A HPLC fraction (fraction 6, Fr-6) isolated from Antrodia camphorata was observed to induce apoptosis in human non-small cell lung carcinoma A549 cell via decreasing the expression level of four tumor-related genes, e.g. calpain 1/2 small subunit, galectin-1, Rho GDP inhibitor [alpha] and eukaryotic translation initiation factor 5A. Author Affiliation: Department of Biotechnology, Southern Taiwan University, 1 Nan-Tai Street, YungKang City, Tainan County 701, Taiwan Article History: Received 27 November 2009; Accepted 2 December 2009

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Gale Document Number: GALE|A218408208