Prandial hypertriglyceridemia in metabolic syndrome is due to an overproduction of both chylomicron and VLDL triacylglycerol

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From: Diabetes(Vol. 62, Issue 12)
Publisher: American Diabetes Association
Document Type: Report
Length: 5,228 words
Lexile Measure: 1470L

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Abstract :

The aim was to determine whether fed VLDL and chylomicron (CM) triacylglycerol (TAG) production rates are elevated in metabolic syndrome (MetS). Eight men with MetS (BMI 29.7 [+ or -] 1.1) and eight lean age-matched healthy men (BMI 23.1 [+ or -] 0.4) were studied using a frequent feeding protocol. After 4 h of feeding, an intravenous bolus of [sup.2][H.sub.5]-glycerol was administered to label VLDL1, VLDL2, and TAG. [sup.13]C-glycerol tripalmitin was administered orally as an independent measure of CM TAG metabolism. Hepatic and intestinal lipoproteins were separated by an immunoaffinity method. In MetS, fed TAG and the increment in TAG from fasting to feeding were higher (P = 0.03 and P = 0.04, respectively) than in lean men. Fed CM, VLDL1, and VLDL2 TAG pool sizes were higher (P = 0.006, P = 0.03, and P

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Gale Document Number: GALE|A353316370