Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media

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Date: Mar. 2003
From: Biotechnology Letters(Vol. 25, Issue 5)
Publisher: Springer
Document Type: Article
Length: 103 words

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Abstract :

Byline: Chun-Sheng Chang (1), Chin-Shuo Hsu (1) Keywords: esterification; lipase; (S)-naproxen hydroxyalkyl ester Abstract: A lipase-catalyzed, enantioselective esterification process in organic solvents was developed for the synthesis of (S)-naproxen hydroxyalkyl ester. With the selection of lipase (Candida rugosa lipase) and reaction medium (isooctane and cyclohexane), a high enantiomeric ratio of < 100 for the enzyme was obtained. 1,4-Butanediol was the best acyl acceptor. The carbon chain length of the alcohol had a major effect on the enzyme activity and enantioselectivity of lipase-catalyzed esterification. Author Affiliation: (1) Department of Biotechnology, Southern Taiwan University of Technology, Tainan Hsien, Taiwan, 710 Article History: Registration Date: 05/10/2004

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Gale Document Number: GALE|A162453809