A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor elF4A

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From: Science(Vol. 334, Issue 6057)
Publisher: American Association for the Advancement of Science
Document Type: Author abstract
Length: 83 words

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Abstract :

The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression Levers of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor elF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1. DOI: 10.1126/science.1211915

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Gale Document Number: GALE|A274025936