Effects of an intensive lifestyle intervention and the role of sleep in people living with HIV and prediabetes: a pilot and feasibility study.

Citation metadata

From: BMC Research Notes(Vol. 14, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 3,632 words
Lexile Measure: 1370L

Document controls

Main content

Abstract :

Objectives Prediabetes is prevalent in people living with HIV (PLWH). Insufficient and irregular sleep are linked to abnormal glucose metabolism. This study aimed to investigate the differences in sleep characteristics between PLWH with and without prediabetes, determine the acceptability/feasibility and effects of a pilot six-month intensive lifestyle intervention (ILI) program on glucose metabolism in those with prediabetes, and determine how sleep modulates these effects. Results Thirty-nine PLWH (20 normoglycemia and 19 prediabetes) participated. There were no differences in sleep characteristics between individuals with normoglycemia and prediabetes. Next, thirteen individuals with prediabetes completed a six-month ILI program. The ILI program resulted in significant body weight reduction at 6 months (63.5 [+ or -] 13.9 to 61.9 [+ or -] 14.0 kg, p = 0.012), which was maintained at 12 months (p Trail registration: ClinicalTrial.gov, NCT03545217 (date of registration: May 22, 2018) Keywords: HIV, Intensive lifestyle intervention, Prediabetes, Sleep

Source Citation

Source Citation   

Gale Document Number: GALE|A661412036