Oxidative-stress-induced biosignatures: a predictor of allograft dysfunction?

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Date: Feb. 25, 2016
From: The Lancet(Vol. 387)
Publisher: Elsevier B.V.
Document Type: Article
Length: 104 words

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Abstract :

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(16)00487-6 Byline: Emily Thompson, John G Brain, Simi Ali, John A Kirby Abstract: Chronic graft dysfunction is the commonest cause of graft loss and is affected by perioperative factors. In liver transplantation, perioperative oxidative stress precipitates a senescence-associated secretory phenotype in biliary epithelial cells and this could be one of the factors responsible for fibrosis and allograft dysfunction. We aimed to examine effects of oxidative stress on biliary epithelial cells and assess the transcriptome of time-zero liver transplant biopsies for biomarkers of allograft dysfunction. Author Affiliation: (a) Newcastle University, Newcastle upon Tyne, UK

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Gale Document Number: GALE|A462212740