Outbreak of hepatitis E with bimodal peak in rural area of Bhavnagar, India, 2010

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Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Report
Length: 3,084 words
Lexile Measure: 1500L

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Byline: Devang. Raval, Naresh. Chauhan, Rajesh. Katara, Pankhuri. Mishra, Dharmendra. Zankar

Context : Rise in the number of jaundice cases were reported on 24 [sup]th of June 2010, in Dhola village, India. We investigated the outbreak to identify the source of infection and to facilitate control measures. Materials and Methods : We confirmed the outbreak by reviewing the rate of acute viral hepatitis in the year 2009-10. We defined a case of acute hepatitis as an acute illness with (a) discrete onset of symptoms and (b) jaundice or elevated serum aminotransferase levels, since March 2010 in Dhola village. We described the outbreak in terms of time, place, and person. We tested 20 blood samples of the case patient for hepatitis B surface antigen (HBs Ag), and immunoglobulin M (IgM) antibody for hepatitis A and E. We collected water samples for the bacteriological examination, and to test free chlorine in the water. Results : A total of 137 cases (attack rate 27.2/1000) were reported in this outbreak from March to August 2010. The attack rate was highest among the age group of 20-29 years. The attack rate was significantly higher in male (35/1000) than in female (18/1000). Out of 20 case-patients, 19 were found positive for hepatitis E virus (HEV) IgM antibodies. The water samples taken from households contained more than 10 coliforms in 100 ml sample. The relative risk of developing hepatitis E among people using pipeline water against those using ground water was 3.23 (95% CI of RR 1.59, 6.57). Conclusion : Outbreak that affected Dhola village was due to hepatitis E virus. Fecal contamination of water was the most likely source of this bimodal outbreak of hepatitis E.

Introduction

Hepatitis E, formerly known as enterically-transmitted non-A, non-B hepatitis, is an acute, icteric, self-limited disease widely spread in Asia, Africa, Middle East, and Central America. [sup][1],[2],[3],[4],[5],[6] Viral hepatitis continues to be a major public health problem in India. [sup][7],[8] Evidence of hepatitis E virus (HEV) was first reported in 1980, in India. [sup][9] The fecal-oral route is the primary mode of transmission of HEV [sup][1] and it is associated with both sporadic infections and epidemics in areas with poor sanitation and weak public-health infrastructures. [sup][4]

HEV is a small RNA virus which belongs to the genus, Hepevirus, of the family, Hepeviridae. [sup][6] Hepatitis E infections occur less frequently in developed countries, and only occur in those individuals who had been infected while traveling in an area where the virus is endemic. [sup][1] However, autochthonous (locally acquired) occurrences of hepatitis E cases were also reported in developed countries, recently. [sup][3],[10],[11],[12] The virus also spreads through person-to-person, but such a spread is less common, and a secondary attack rate ranges from 0.7% to 2.2% among susceptible household contacts of patient. [sup][13] The incubation period ranges from 2 weeks to 2 months, usually 1 month to 45 days. [sup][7] Pregnant women affected by acute viral hepatitis E are more likely to develop acute liver failure (ALF); however, the fatal outcome may remain...

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Gale Document Number: GALE|A297485621