Molecular evidence of oysters as vehicle of norovirus GII.P17-GII.17

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From: Emerging Infectious Diseases(Vol. 22, Issue 11)
Publisher: U.S. National Center for Infectious Diseases
Document Type: Letter to the editor
Length: 1,159 words
Lexile Measure: 1350L

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To the Editor: Norovirus is the world's leading cause of nonbacterial acute gastroenteritis (1). Since their emergence, GII.P17-GII.17 noroviruses have replaced the GII.4 Sydney 2012 variant as the dominating norovirus genotype in parts of Asia (2), although they have been detected only sporadically, in a limited number, on other continents (3).

The major reservoir(s) of GII.17 that contribute to transmission are unknown, but it has been suggested that oysters and other bivalve shellfish are common vehicles for transmission of the emerging GII.17 viruses (2). In this study, we demonstrate the link between oysters and human disease by presenting molecular evidence of norovirus GII. P17-GII.17 in Denmark causing acute gastroenteritis, characterized by the sudden onset of vomiting with or without diarrhea after consumption of oysters. We further document molecular evidence providing linkage between norovirus detected in fecal samples from patients and food samples from imported oysters.

During January 23-February 4, 2016, acute gastroenteritis developed in 58 of 67 persons who consumed oysters served on 18 separate occasions at 8 different restaurants and a private party, with onset of symptoms within 24-40 hours after the patients ate oysters. All oysters originated from 2 distinct oyster lots provided by 1 wholesaler in France and distributed by 1 wholesaler in Denmark. Oysters from both lots were harvested off the coast of La Rochelle, France.

In Denmark, submitting fecal samples in connection with foodborne outbreaks is voluntary. A total of 5 samples from 3 cases representing 2 different parties were submitted to the National Virus Surveillance Laboratory at Statens Serum Institut (Copenhagen, Denmark) for norovirus analysis. In addition, 4 samples of oysters from the same producer in France were sent to the National Food Institute, Technical University of Denmark (Kongens Lyngby, Denmark), for norovirus...

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Gale Document Number: GALE|A472266346