Clinical, epidemiological, and microbiological profile of patients with vancomycin-resistant Enterococci from a Tertiary Care Hospital

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From: Journal of Global Infectious Diseases(Vol. 4, Issue 2)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Letter to the editor; Report
Length: 1,027 words
Lexile Measure: 1380L

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Byline: P. Vidyalakshmi, R. Gopalakrishnan, V. Ramasubramanian, K. Ghafur, P. Nambi, M. Thirunarayana


Progress in medical technology and the intensive use of broad spectrum antibiotics have been responsible for the emergence of Enterococci as important nosocomial pathogens. Although the frequency of isolation of Vancomycin-Resistant Enterococci (VRE) is currently not very high in India, [sup][1] this may just be the beginning of the problem, in contrast to the USA and Europe, where VRE appeared in the late 1980s.

Treatment options and effective antimicrobial agents for VRE are often limited and the possibility of the transfer of vancomycin-resistant genes to other Gram-positive microorganisms remains.

We attempted to analyze the clinical, microbiological, and epidemiological features of patients who were culture positive for VRE in a tertiary care hospital in Southern India.

The study was performed at a 600-bed tertiary care hospital, which also conducted kidney and liver transplants. The medical records of 18 patients with a positive culture for VRE were reviewed. A microbiological data analysis was done, which included minimum inhibitory concentration (MIC) to various drugs. The MIC was estimated using the E test. MICs were interpreted based on the latest Clinical and Laboratory Standards Institute (CLSI) guidelines. [sup][2]

In North America and Europe, VRE now accounts for about 30% of the Enterococcal infections, with most VRE isolates being E. faecium (>90%). [sup][3] In our study VRE was isolated in 18 [4%] out of 450 isolates of Enterococci , all isolates being E. faecium, similar to a study from North India which also had the same species...

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Gale Document Number: GALE|A293464980