Sesame (Sesamum indicum L.) is the leading oil seed crop produced in Ethiopia. It is the second most important agricultural commodity for export market in the country. It is well suited as an alternative crop production system, and it has low crop water requirement with moderate resistance to soil moisture deficit. The low land of North Western Ethiopia is the major sesame producer in the country, and the entire production is from rainfed. The rainfall distribution in North Western Ethiopia is significantly varied. This significant rainfall variability hampers the productivity of sesame. Irrigation agriculture has the potential to stabilize crop production and mitigate the negative impacts of variable rainfall. This study was proposed to identify critical growth stages during which sesame is most vulnerable to soil moisture deficit and to evaluate the crop water productivity of sesame under deficit irrigation. The performance of sesame to stage-wise and uniform deficit irrigation scheduling technique was tested at Gondar Agricultural Research Center (Metema Station), Northern Western Ethiopia. Eight treatments, four stage-wise deficit, two uniform deficit, one above optimal, and one optimal irrigation applications, were evaluated during the 2017 irrigation season. The experiment was designed as a randomized complete block design with three replications. Plant phenological variables, grain yield and crop water productivity, were used for performance evaluation. The result showed that deficit irrigation can be applied both throughout and at selected growth stages except the midseason stage. Imposing deficit during the midseason gave the lowest yield indicating the severe effect of water deficit during flowering and capsule initiation stages. When deficit irrigation is induced throughout, a 25% uniform deficit irrigation can give the highest crop water productivity with no or little yield reduction as compared with optimal irrigation. Implementing deficit irrigation scheduling technique will be beneficial for sesame production. Imposing 75% deficit at the initial, development, late season growth stages or 25% deficit irrigation throughout whole seasons will improve sesame crop water productivity.