MiR-149-5p promotes [beta]-catenin-induced goat hair follicle stem cell differentiation.

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Date: Apr. 2022
Publisher: Springer
Document Type: Report; Brief article
Length: 178 words

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Abstract :

Keywords: miR-149-5p; [beta]-catenin; C-myc; Krt6; Differentiation Abstract The Yangtze River Delta white goat is a unique goat species that can produce superior-quality brush hair. The formation of superior-quality brush hair cannot occur without goat hair follicle stem cell differentiation. However, knowledge regarding the regulatory role of miR-149-5p in hair follicle stem cell differentiation is limited. Here, we found that miR-149-5p is widely expressed in the tissues of Yangtze River Delta white goats, but its expression in the skin tissue of superior-quality brush hair goats is high compared to normal- quality goats. The functional studies showed that miR-149-5p overexpression markedly facilitated hair follicle stem cell differentiation, whereas inhibiting miR-149-5p inhibited hair follicle stem cell differentiation. These results more clearly elucidate the regulatory role of miR-149-5p in hair follicle stem cell growth. Author Affiliation: (1) College of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, Jiangsu, China (2) Key Laboratory of Animal Genetics & Molecular Breeding of Jiangsu Province, Yangzhou University, Yangzhou, China (h) liyj@yzu.edu.cn Article History: Registration Date: 03/18/2022 Received Date: 08/19/2021 Accepted Date: 03/12/2022 Online Date: 04/14/2022 Byline:

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Gale Document Number: GALE|A702795693