Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures

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Publisher: National Academy of Sciences
Document Type: Author abstract
Length: 242 words

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Abstract :

Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent. Here, we report the simultaneous introduction and overexpression of genes encoding the rate-limiting upstream enzyme putrescine N-methyltransferase (PMT) and the downstream enzyme hyoscyamine 6 [beta]-hydroxylase (H6H) of scopolamine biosynthesis in transgenic henbane (Hyoscyamus niger) hairy root cultures. Transgenic hairy root lines expressing both pmt and h6h produced significantly higher (P Agrobacterium | hyoscyamine 6[beta]-hydroxylase | putrescine N-methyltransferase | scopolamine | transformation

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Source Citation   

Gale Document Number: GALE|A117260191