Neisseria meningitidis serogroup X sequence type 2888, Italy

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From: Emerging Infectious Diseases(Vol. 16, Issue 2)
Publisher: U.S. National Center for Infectious Diseases
Document Type: Case study; Letter to the editor
Length: 818 words
Lexile Measure: 1290L

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To the Editor: Neisseria meningitidis serogroup X was first described in the 1960s and has been found to be responsible of rare cases of invasive meningococcal diseases, in particular, meningitis, in North America, Europe, Australia, Africa, and the People's Republic of China (1-3). This serogroup has recently emerged in Africa as an increasing cause of meningitis; unfortunately, it is not covered by current vaccine programs. Serogroup X outbreaks have been reported in Niger, Ghana, and Kenya (4-6). In particular, in Niger during January-June 2006, N. meningitidis serogroup X represented 51% of confirmed cases of meningitis (4).

To investigate the population structure of serogroup X meningococci isolated during recent decades in Africa, Europe, and North America, Gagneux et al. (1) compared the molecular characteristics among them. That study highlighted a low genetic variability between African serogroup X strains, which contrasts with higher genetic variability among isolates from Europe and the United States (1).

We describe a case of invasive meningococcal disease caused by a serogroup X N. meningitidis strain isolated in Italy. The patient was a 55-year-old Italian woman with no immune deficiency. The onset of disease started quickly with high fever (39[degrees]C) on June 1, 2009. No contacts with persons coming from abroad were...

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Gale Document Number: GALE|A221918684