Protective role of turmeric on histological, ultrastructural and serobiochemical changes in cisplatin-induced nephrotoxicity in female rats

Citation metadata

From: Veterinary World(Vol. 6, Issue 11)
Publisher: Veterinary World
Document Type: Report
Length: 2,808 words
Lexile Measure: 1450L

Document controls

Main content

Abstract :

Aim: Protective role of turmeric was assessed against cisplatin-induced histological and ultra-structural changes in kidney. Materials and Methods: A total of 48 rats were divided into 4 groups of 12 rats in each. Group 1 was kept as sham control, group 2 was treated with cisplatin (@ 2 mg/kg b.wt, intraperitoneally on day 1, 7, 14 and 21), group 3 with turmeric (@ 0.05 mg/kg b.wt. p.o. once daily for 28 days) and group 4 with cisplatin + turmeric (as per above schedule). Blood was collected at fortnight intervals and serum was separated for estimation of kidney biomarkers. Six rats in each group were then euthanized on day 14 and 28 for histopathology, and tissue parameters were assayed on day 28. Results: Thibarbituric acid reacting substances (TBARS), protein carbonyls, serum creatinine, blood urea nitrogen (BUN) were significantly (P Conclusion: The study revealed that cisplatin induces nephrotoxicity due to oxidative stress and turmeric was found beneficial in countering the adverse effects. Key words: cisplatin, nephrototoxicity, oxidative stress, turmeric.

Source Citation

Source Citation   

Gale Document Number: GALE|A356808507