Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake

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From: The Journal of Nutrition(Vol. 144, Issue 9)
Publisher: American Institute of Nutrition
Document Type: Author abstract; Report
Length: 365 words

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Abstract :

Aging is often associated with overweight and obesity. There exists a long-standing debate about whether meal pattern also contributes to the development of obesity. The orexigenic hormone ghrelin regulates appetite and satiety by activating its receptor, growth hormone secretagogue receptor (GHS-R). In mice, circulating ghrelin concentrations and brain GHS-R expression were shown to increase with aging. To assess whether GHS-R regulates feeding pattern during aging, we studied meal patterns for the following cohorts of male mice fed a normal unpurified diet: 7) 3-4 mo, young wild-type (WT) mice; 2) 3-4 mo, young Gbsr-null ([Ghsr.sup.-/-]) mice; 3) 12-14 mo, middle-aged WT (WT-M) mice; 4) 12-14 mo, middle-aged [Ghsr.sup.-/-] ([Ghsr.sup.-/-]-M) mice; 5) 24-26 mo, old WT (WT-O) mice; and 6) 24-26 mo, old [Ghsr.sup.-/-] ([Ghsr.sup.-/-]-O) mice. Although the total daily food intake of [Ghsr.sup.-/-] mice was similar to that of WT controls, [Ghsr.sup.-/-]-M and [Ghsr.sup.-/-]-O mice had 9% (P = 0.07) and 16% (P doi:10.3945/jn.114.191171.

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Gale Document Number: GALE|A381587220