Ferritin heavy chain upregulation by NF-KappaB inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species

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From: Cell(Vol. 119, Issue 4)
Publisher: Elsevier B.V.
Document Type: Article
Length: 54 words

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Abstract :

A ferritin heavy chain (FHC), the primary iron storage factor, is identified in a study as an essential mediator of the antioxidant and protective activities of NF-KappaB. The antiapoptotic activity of FHC functions to inhibit induction of reactive oxygen species (ROS) and, thereby, activation of c-Jun N-terminal kinase (JNK) by tumor necrosis factor (TNF)alpha.

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Gale Document Number: GALE|A127032979