Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity

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Date: Mar. 22, 2011
From: Biochemistry(Vol. 50, Issue 11)
Publisher: American Chemical Society
Document Type: Report
Length: 80 words

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Abstract :

Studies about the assembly and stability of multiprotein base excision repair (BER) proteins in vivo with abasic DNA and the role of adenomatous polyposis coli (APC) protein as well as the physical and functional activity of the associated proteins are presented. Major BER proteins in the complex are assembled onto F-DNA and are competent in performing DNA repair while the reduced activity in the wild-type APC in the BER is attributed to the interaction with multiple components of the system.

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Gale Document Number: GALE|A254444656