Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure

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From: Journal of Perinatology(Vol. 33, Issue 12)
Publisher: Nature Publishing Group
Document Type: Report
Length: 4,813 words
Lexile Measure: 1720L

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Abstract :

OBJECTIVE: We conducted a post-hoc analysis of early inhaled nitric oxide (iNO)-randomized controlled trial data to identify associations pertinent to the management of moderate hypoxic respiratory failure in term/late preterm infants. STUDY DESIGN: Univariate and multivariate logistic regression analyses were used to determine risk factors for the progression of respiratory failure and extracorporeal membrane oxygenation (ECMO)/death. RESULT: Among the 299 enrolled infants, oxygenation index (OI) 30 (P = 0.002) and to composite outcome of OI 30 or ECMO/death (P = 0.02). CONCLUSION: This post-hoc analysis suggests that early use of surfactant and iNO in moderate respiratory failure is associated with improved outcomes. Journal of Perinatology (2013) 33, 944-949; doi: 10.1038/jp.2013.83; published online 18 July 2013 Keywords: newborn; lung disease; persistent pulmonary hypertension of the newborn; PPHN; ECMO

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Gale Document Number: GALE|A353518344