Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes

Citation metadata

Publisher: Hindawi Limited
Document Type: Report
Length: 3,685 words
Lexile Measure: 1290L

Document controls

Main content

Abstract :

Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis. Taken together, this suggests a probable network among fat, bone, and muscle that may influence health outcomes. The aims of this study were to investigate the relationship of circulating sclerostin and irisin and their association with adiposity (assessed by body mass index (BMI)). Materials/Methods. A cross-sectional study included 98 adults with impaired fasting glucose and/or impaired glucose tolerance. 75 gm OGTT was performed in all subjects. Fasting plasma samples were obtained for glycated hemoglobin, calcium, creatinine, serum sclerostin and irisin. Results. Circulating irisin and sclerostin were highly correlated (r = -0.4; P

Source Citation

Source Citation   

Gale Document Number: GALE|A418467271