Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair

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From: Biochemistry(Vol. 45, Issue 51)
Publisher: American Chemical Society
Document Type: Report
Length: 76 words

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Abstract :

An investigation is carried out to determine the mechanism of the role of adenomatous polyposis coli (APC) in long-patch base excision repair (LP-BER) through its interaction with DNA polymerase (pol-beta) and flap endonuclease (Fen-1). The outcomes lead to the inference that APC exerts three different impacts on the LP-BER pathway by blocking pol-beta-mediated 1-nt incorporation and strand-displacement synthesis, by blocking the coordinated formation and removing the stranded-displaced flap, and by blocking LP-BER by obstructing hit-and-run synthesis.

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Gale Document Number: GALE|A158503741