Abstract :
Byline: Sangwon Han (1,2), Hyesung Kim (3), Yeon Joo Kim (4), Chong Hyun Suh (1,5), Sungmin Woo (1,6) Keywords: PET; Ovarian cancer; Metabolic tumor volume; Total lesion glycolysis; Prognosis Abstract: Objective To perform a systematic review and meta-analysis on the prognostic value of 18.sup.F-FDG PET-derived volume-based parameters regarding metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with ovarian cancer. Methods Pubmed and EMBASE databases were searched up to February 12, 2018 for studies which evaluated MTV or TLG as a prognostic factor in ovarian cancer with progression-free (PFS) and overall survival (OS) as the endpoints. Hazard ratios (HRs) were meta-analytically pooled using the random-effects model. Multiple subgroup analyses based on clinicopathological and PET variables were performed. Results Eight studies with 473 patients were included. The pooled HRs of MTV and TLG for PFS were 2.50 (95% CI 1.79--3.48 p Conclusions MTV and TLG from 18.sup.F-FDG PET were significant prognostic factors in patients with ovarian cancer. Despite the clinical heterogeneity and difference in methodology between the studies, patients with a high MTV or TLG have a higher risk of disease progression or death. Author Affiliation: (1) Meta-analysis for Imaging studies on Diagnostic test Accuracy and prognosiS (MIDAS) group, Seoul, Republic of Korea (2) 0000 0001 0842 2126, grid.413967.e, Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (3) 0000 0004 0470 5905, grid.31501.36, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea (4) 0000 0004 1803 0072, grid.412011.7, Department of Radiation Oncology, Kangwon National University Hospital, Chuncheon, South Korea (5) 0000 0001 0842 2126, grid.413967.e, Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (6) 0000 0004 0470 5905, grid.31501.36, Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea Article History: Registration Date: 09/08/2018 Received Date: 14/06/2018 Accepted Date: 08/08/2018 Online Date: 12/08/2018