Background and Aim: The potential solution is to use agro-industrial by-products as an unconventional source of raw materials for broiler feed. This study aims to determine the effects of substituting prickly pear (FB; Opuntia ficus-indica) husks for corn and FB seed cake for soybean meal on the production performance, slaughter characteristics, and chemical composition of broiler meat. Materials and Methods: Two hundred day-old chicks of equal sex ratio (1:1) of Big Fast strain, weighing on average 37 [+ or -] 2g, were randomly divided into four homogeneous groups of 50 subjects each. Each group was subdivided into 10 packs of five animals, which were banded and numbered. Rations with substitution rates of 0%, 10%, 20%, and 30% of corn and soybean meal by dehydrated husks and FB cake were randomly distributed among the groups. Results: Average daily gains and body weights on 48 days were improved (p Conclusion: Incorporating FB processing by-products into broiler feed at rates of 10% and 20% improves zootechnical performance, carcass yields, and the chemical composition of the meat. Keywords: broiler feed, prickly pear processing, production cost.