Oral immunogenicity of plant-made Mycobacterium tuberculosis ESAT6 and CFP10

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Publisher: Hindawi Limited
Document Type: Report
Length: 4,834 words
Lexile Measure: 1430L

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Abstract :

Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis.

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Gale Document Number: GALE|A427022577