Dissection of Protein Interactomics Highlights MicroRNA Synergy

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Date: May 14, 2013
From: PLoS ONE(Vol. 8, Issue 5)
Publisher: Public Library of Science
Document Type: Article
Length: 8,508 words
Lexile Measure: 1460L

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Abstract :

Despite a large amount of microRNAs (miRNAs) have been validated to play crucial roles in human biology and disease, there is little systematic insight into the nature and scale of the potential synergistic interactions executed by miRNAs themselves. Here we established an integrated parameter synergy score to determine miRNA synergy, by combining the two mechanisms for miRNA-miRNA interactions, miRNA-mediated gene co-regulation and functional association between target gene products, into one single parameter. Receiver operating characteristic (ROC) analysis indicated that synergy score accurately identified the gene ontology-defined miRNA synergy (AUC = 0.9415, p

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Gale Document Number: GALE|A478277195