Nuclear [beta]-Catenin Expression is Frequent in Sinonasal Hemangiopericytoma and Its Mimics

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Date: June 2017
From: Head and Neck Pathology(Vol. 11, Issue 2)
Publisher: Springer
Document Type: Report
Length: 329 words

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Abstract :

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12105-016-0737-2 Byline: Vickie Y. Jo (1), Christopher D. M. Fletcher (1) Keywords: [beta]-Catenin; Sinonasal hemangiopericytoma; Sinonasal; Soft tissue; Solitary fibrous tumor; Synovial sarcoma; Myopericytoma Abstract: Sinonasal hemangiopericytoma (HPC) is a tumor showing pericytic myoid differentiation and which arises in the nasal cavity and paranasal sinuses. CTNNB1 mutations appear to be a consistent aberration in sinonasal HPC, and nuclear expression of [beta]-catenin has been reported. Our aim was to evaluate the frequency of [beta]-catenin expression in sinonasal HPC and its histologic mimics in the upper aerodigestive tract. Cases were retrieved from the surgical pathology and consultation files. Immunohistochemical staining for [beta]-catenin was performed on 50 soft tissue tumors arising in the sinonasal tract or oral cavity, and nuclear staining was recorded semiquantitatively by extent and intensity. Nuclear reactivity for [beta]-catenin was present in 19/20 cases of sinonasal HPC 17 showed moderate-to-strong multifocal or diffuse staining, and 2 had moderate focal nuclear reactivity. All solitary fibrous tumors (SFT) (10/10) showed focal-to-multifocal nuclear staining, varying from weak to strong in intensity. Most cases of synovial sarcoma (9/10) showed nuclear [beta]-catenin expression in the spindle cell component, ranging from focal-weak to strong-multifocal. No cases of myopericytoma (0/10) showed any nuclear [beta]-catenin expression. [beta]-catenin expression is prevalent in sinonasal HPC, but is also frequent in SFT and synovial sarcoma. Our findings indicate that [beta]-catenin is not a useful diagnostic tool in the evaluation of spindle cell tumors with a prominent hemangiopericytoma-like vasculature in the sinonasal tract and oral cavity, and that definitive diagnosis relies on the use of a broader immunohistochemical panel. Author Affiliation: (1) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA Article History: Registration Date: 09/06/2016 Received Date: 11/05/2016 Accepted Date: 08/06/2016 Online Date: 20/06/2016 Article note: These results were presented in part at the 105th Annual Meeting of the US-Canadian Academy of Pathology, Seattle, March 2015.

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Gale Document Number: GALE|A491616888