Detection of autoreactive [CD4.sup.+] T cells by MHC class II multimers in HLA-linked human autoimmune diseases.

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Date: May 1, 2021
From: Journal of Clinical Investigation(Vol. 131, Issue 9)
Publisher: American Society for Clinical Investigation
Document Type: Article
Length: 2,000 words
Lexile Measure: 1490L

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Abstract :

Recognition of self-peptides in association with distinct HLA class II alleles by autoreactive [CD4.sup.+] T cells is central for loss of immunological tolerance leading to autoimmune disease. However, identifying immunodominant self-peptides and characterizing autoreactive T cells is challenging. In this issue of the JCI, Falta et al. identify a disease-associated complementarity-determining region 3p motif specific for beryllium-modified C-C motif ligand 4 (CCL4) and CCL3 self-peptides in patients with chronic beryllium disease (CBD), a granulomatous lung disorder with a known HLA class II allelic association. Detection of these antigen-specific [CD4.sup.+] T cells by beryllium-pulsed HLA-DP2 tetramers presenting CCL4/CCL3 confirms these autoantigens in humans and mice and enables monitoring in the progress of disease. Detection of autoreactive [CD4.sup.+] T cells by peptide-MHC class II multimers allows for the detailed characterization of disease-promoting T cells. This knowledge has profound implications for the monitoring and development of targeted therapies in human autoimmune disorders.

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Gale Document Number: GALE|A661688804