Alterations of the Ileal and Colonic Mucosal Microbiota in Canine Chronic Enteropathies

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From: PLoS ONE(Vol. 11, Issue 2)
Publisher: Public Library of Science
Document Type: Report
Length: 6,983 words
Lexile Measure: 1530L

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Abstract :

Background The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon. Aim To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls. Methods Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by fluorescence in situ hybridization (FISH) on a quantifiable basis. Results The ileal and colonic mucosa of healthy dogs and dogs with CE is predominantly colonized by bacteria localized to free and adherent mucus compartments. CE dogs harbored more (P Conclusion Pathogenic events in canine CE are associated with different populations of the ileal and colonic mucosal microbiota.

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Gale Document Number: GALE|A442170417